​NOISOME, harmful, offensive, especially of that which causes physical disgust. The word is formed from the obsolete “ noy,” trouble, a shortened form of “ annoy,” now only used as a verb, to cause trouble, the usual substantive being “ annoyance.” The O. Fr. anoi, anui (modern ennui) is an adaptation of Lat. in odio esse, venire or habere, to be sick, tired of anything (odium, disgust, hatred). The word has no connexion with Lat. nocere, to hurt.