​PILOCARPINE, CuH16N2O2, an alkaloid found, together with isopilocarpine and other related compounds, in the leaves of jaborandi (Pzlocarpus pennatzfolzus). It was first isolated by E. Hardy in 1875 (Ben, 8, p 1594), and is a crystalline, very hygroscopic solid It is a strong poison. It has the properties of a monacid base and contains the methyl amino group, -NCH3 when heated with hydrochloric acid it gives isopilocarpine Isopilocarpine was isolated in 1900 by H A. D. ]owett (J own. Chem Soc 77, p. 473), and is a colourless oil which boils at 261° C (10 mm) It is a monacid base which is readily soluble in solutions of the causi ic alkalis ]owett is of the opinion that pilocarpine and isopilocarpine are stereo-isomers of the structure - /CH.jF1.CH3C, H5.(fH.CQO