inoculation. That it can be of much longer duration is equally certain. I have seen an unquestionable oriental sore which did not appear until five months after the patient had been exposed to any possibility

of infection. Wenyon inoculated himself with oriental sore in Aleppo; it was not until six and a half months later that a leishmania-containing papule, subsequently developing into a sore, appeared at the site of inoculation. In other cases the incubation